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H.-P. Hammes

Diabetic microangiopathy: vascular cell crosstalk in hyperglycaemia

Diabetic retinopathy is the most common microvascular complication in diabetes mellitus, mostly determined by chronic glycaemia as measured by HbA1c. The sequence of events involves changes in the cellular crosstalk of the retinal capillary, initiated by the loss of intramural pericytes. Data from transgenic and diabetic models allow to assess the relative importance of this phenomenon. New insight into biochemical and cell biological interactions from hyperglycaemia to vascular injury establish metabolic signal blockers as novel therapeutic approaches for diabetic microangiopathy.

Hämostaseologie, Schattauer

Print ISSN: 0720-9355
Volume: 25, 01/2005
Pages: 18 - 22

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