Science.Online
Search
Publisher and Institutes
Akademie Verlag
Deutsches Institut für Urbanistik
Oldenbourg Wissenschaftsverlag
Walter de Gruyter
Schattauer
You are here: Home :: Area NEM :: Medical science :: Human medicine :: Nuclear medicine
 
M. Gutberlet, S. Mehl, M. Frhlich, H. Hausmann, M. Plotkin, J. Ruf, T. Denecke, B. Spors, M. Grothoff, R. Hetzer, R. Felix, H. Amthauer

Determination of ventricular volumes in coronary artery disease: Comparison of two gated SPECT analysis tools with MRI

Keywords: Gated SPECT, cardiac volumetry, cardiac MRI, myocardial scar, coronary artery disease, Heart failure

Aim: Comparison of two gated SPECT analysis tools gated SPECT quantification (GSQ) and emory cardiac toolbox (ECT) in patients with coronary artery disease (CAD) and severely impaired left ventricular function (preoperative: EF <35% by cardiac catheter). Patients, methods: A total of 56 gatedSPECT examinations (one-day hybrid-protocol with 201Tl-chloride for rest and 99mTc-sestamibi for stress applied during low-dose dobutamine stress MR-examination; temporal resolution; 8 phases per cardiac cycle) were performed in 36 patients (31 preoperatively, 25 postoperatively) and compared with MRI in 48 cases. Left ventricular end-diastolic (LV-EDV) and end-systolic (LV-ESV) volumes as well as the left ventricular ejection fraction (LV-EF) were calculated. Results: The total volumetric assessment by both analysis algorithms (n = 56) showed good intraclass correlation coefficients preoperatively (n = 31), but even better postoperatively (n = 25). The mean reconstruction time was approximately 3 minutes ( 2 SD) for GSQ and 15 minutes ( 5 SD) for ECT. In comparison to MRI the results of both analysis tools also correlated well, but the agreement decreased in the presence of scared tissue. The mean LV-EF (MRI) preoperatively was 30.4%, in 6/36 patients above the values calculated from cardiac catheter, postoperatively 34.6%. Conclusion: Both gated SPECT analysis tools showed reliable volumetric assessments in high-risk patients with CAD and severely reduced LV-EF in comparison to MRI, with advantages for GSQ in terms of postprocessing time. However, for the calculation of LV-EF a markedly lower concordance with MR-results was observed for both methods depending on the presence of myocardial scars.

Nuklearmedizin, Schattauer

Print ISSN: 0029-5566
Volume: 45, 01/2006
Pages: 63 - 73

Show full article (external site)

Show all available items of this journal