Lidia Sugherini, Melissa Valentini, Caterina Cambiaggi, Italo Tanganelli, Giorgio Gragnoli, Patrizia Borgogni, Mario Comporti, Alfonso Pompella
Determination of a Redox Compensation Index and Its Relationships to Glycaemic Control in Type 2 Diabetes Mellitus
The measurement of single parameters of oxidative
stress in biological fluids can often give results difficult
to interpret as to the real involvement of oxidative
processes in a given disease condition. In the present
study we propose a novel integrated parameter, called
“redox compensation index”, obtained by combining
the results of two established and convenient procedures,
i.e. the Fox-2 assay for plasma lipid hydroperoxides
and the ferric reducing/antioxidant power (FRAP)
assay for total antioxidant potential of plasma. These
procedures were employed for the evaluation of oxidative
stress in a group of patients with type 2 diabetes
mellitus, a condition in which oxidative processes are
implicated in the development of complications. In type
2 diabetic patients, plasma lipid hydroperoxides were
directly correlated with levels of glycated hemoglobin.
On the other hand, a significant inverse correlation was
o b s e rved between levels of glycated hemoglobin and
redox compensation values. The data reported suggest
that the redox compensation index could represent a
convenient parameter for the direct appraisal of oxidative
status in clinical subjects, and are in support of the
proposed role of protein glycation in production of oxidative
alterations during type 2 diabetes mellitus.
Clinical Chemical Laboratory Medicine, Walter de Gruyter
Print ISSN: 1434-6621
Volume: 38, 10/2000
Pages: 983 - 987
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