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S. zer, G. Dobrozemsky, O. Kienast, M. Beheshti, A. Becherer, B. Niederle, F. Kainberger, R. Dudczak, A. Kurtaran
Value of combined XCT/SPECT technology for avoiding false positive planar 123I-MIBG scintigraphy
Keywords: Phaeochromocytoma, MIBG scintigraphy, XCT/SPECT, image fusion
Aim: The clinical value of combined XCT/SPECT technology in a single device in patients undergoing 123I-MIBG scintigraphy was analyzed. Methods: 31 patients (19 men, 12 women; mean age 55 years, range: 3179 years) demonstrating focal accumulation in planar 123I-MIBG scan were further investigated with a double headed gamma camera with an X-ray tomograph mounted on the same gantry (GE Medical Systems, Millennium VG with Hawkeye, Milwaukee, USA) for anatomical definition of the focal 123I-MIBG uptake. The patients were referred to 123I-MIBG scintigraphy because of biochemically (81%) and/or clinically (19%) suspected pheochromocytoma. Results: In 23 out of 31 patients (74%) the fused images demonstrated physiological accumulation (i. e. intestinal, renal) of 123I-MIBG. In two patients (6%) suspected adrenal MIBG-accumulation was caused by inhomogeneous liver uptake. In two patients (6%) focal abdominal accumulation was correctly localised in the adrenal glands. Furthermore, the differentiation of bone metastasis from a local recurrence for phaeochromocytoma was accurately possible for two patients (6%). Adrenal lesions mimicking liver foci were correctly localised in the remaining two patients (6%). Conclusion: Our study demonstrates the clinical value of XCT/SPECT in a single device in patients demonstrating focal 123I-MIBG uptake in planar scintigraphy. The combined XCT/SPECT technology provides a higher diagnostic accuracy.
Nuklearmedizin, Schattauer
Print ISSN: 0029-5566
Volume: 43, 01/2004
Pages: 164 - 170