Satoshi Kusuda, Yuri Ito, Tae-Jang Kim, Nobuhiro Miyagi, Norio Shishida, Yuko Tanaka
Cerebral hemodynamics after exogenous surfactant administration for respiratory distress syndrome in piglet model
Objective: The rapid improvement of lung function after
exogenous surfactant treatment for respiratory distress
syndrome (RDS) can affect the functions of several
other systems, which includes cerebral blood flow
volume (CBF). To evaluate the change in CBF after
treatment with exogenous surfactant, we measured CBF
in a newborn piglet model with RDS.
Method: After the lung lavage with normal saline, ten
animals under mechanical ventilation were administered
either 120 mg/kg surfactant-TA (Surfacten®) or air
placebo. Heart rate, blood pressure, dynamic lung compliance
(Cdyn), PaO2, PaCO2, and CBF were recorded
before and every 15 min after surfactant treatment up
to 120 min.
Results: Cdyn was improved significantly at 45 min
and later after treatment; that of the control group remained
unchanged. PaO2 increased and PaCO2 decreased
significantly after surfactant treatment in both
groups. However, the improvement was significantly
less in the control group. CBF significantly decreased
by about 30% in the control group, and by about 50%
in the treated group at 120 min, with a significant difference
between groups. Almost 70% of the changes in
CBF were attributable to changes in PaCO2 by multivariate
regression analysis.
Conclusions: Treatment with exogenous surfactant improves
lung compliance, and has little effect on CBF
itself. The drop in levels of PaCO2 after treatment, however,
had a strong relationship with decreases in CBF.
Journal of Perinatal Medicine, Walter de Gruyter
Print ISSN: 1619-3997
Volume: 28, 09/2000
Pages: 363 - 371
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