Céline Pallaud, Chiara Stranieri, Catherine Sass, Gérard Siest, Franco Pignatti, Sophie Visvikis
Candidate Gene Polymorphism in Cardiovascular Disease: A Comparative Study of Frequencies between a French and an Italian Population
A multilocus assay was used to genotype up to 27 variable
sites in 15 genes in French and Italian, presumed
to be healthy populations (n=1480, n=162, respectively).
These genes are involved in lipid metabolism
(APOE, APOB, APOC3, CETP, LPL, PON), homocysteine
metabolism (CBS, MTHFR), blood viscosity (Fibrinogen,
FV), platelet aggregation (GpIIIa), leukocyte adhesion
(SELE), and renin-angiotensin system (AT1R, ACE,
AGT). Allele frequencies for all the markers were compared
between the two populations. Five allele frequencies
differed between the two European countries:
APOB 71Ile (p ?0.001), SELE 98T (p ? 0.001), SELE
128Arg (p ?0.01), APOE ?4 (p ? 0.01) and MTHFR 677T
(p ?0.01), suggesting the existence of a north-south
gradient in European allele frequencies. The other allele
frequencies : APOC3 ?482T, ?455C, 1100T, 3175G,
3206G; LPL ?93G, 9Asn, 291Ser; CETP 405Val; PON
192Arg ; ACE Del; AGT 235Thr; AT1R 1166C; CBS
278Thr, GpIIIa P1A2; Fibrinogen ?455A, FV 506Gln and
SELE 554Phe, were similar between the two populations.
They were also similar to those observed in other European countries.
Clinical Chemical Laboratory Medicine, Walter de Gruyter
Print ISSN: 1434-6621
Volume: 39, 04/2001
Pages: 146 - 154
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