R. Blatz, A. Kruppa, A. C. Rodloff
Aviditätsuntersuchungen spezifischer IgG in Seren von Syphilispatienten / Investigations of avidity of specific IgG in sera of patients with syphilis
Summary
Background: Syphilis is among the infections that are
characterized best by serologic methods. Nevertheless,
in single cases evaluation may be difficult. The aim of
this study was to investigate the avidity of specific IgG
to achieve additional information.
Patients and methods: In 182 previously analyzed
sera from syphilitic patients the avidity of Treponema pallidum-
specific IgG was estimated by means of ELISA
(endpoint detection).
Results: Treponema pallidum-specific IgG reached
postinfectious avidity values of 20% after about four
weeks and of 40% after six months without therapy. Values
above 60% could be detected only in special cases.
Between avidity and specific IgM–but not avidity and
Cardiolipin microflocculation test -, a reverse proportional
relationship exists. Persistence of specific IgM is evidenced
by the avidity values.
Conclusions: Avidity detection of specific IgG gives
evidence of the time of primary infection. The estimation
of avidity besides conventional diagnostics in syphilis
may confirm cases suspected of reinfections, give additional
information in problematic cases or in cases for an
expert's certificate.
LaboratoriumsMedizin, Walter de Gruyter
Print ISSN: 0025-8466
Volume: 28, 04/2004
Pages: 154 - 159
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