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Jochen Seissler, Werner A. Scherbaum

Autoimmune diagnostics in diabetes mellitus

Keywords: autoantibodies, Diabetes mellitus, glutamic acid decarboxylase, insulin autoantibodies, latent autoimmune diabetes in adults (LADA), type 1 diabetes, tyrosine phosphatase IA-2

Type 1 diabetes results from a specific destruction of the insulin-producing ?-cells of the pancreas. The disease is characterized by the appearance of specific autoantibodies against islet cell antigens. Autoantibodies to insulin, glutamic acid decarboxylase, tyrosine phosphatase IA-2 and cytoplasmic islet cell antibodies are useful markers for the differential diagnosis of type 1 diabetes when clinical and metabolic criteria alone do not allow definite classification. Autoimmune diagnostics is of particular importance in adults to discriminate between type 1 and type 2 diabetes and to assess the diagnosis of latent autoimmune diabetes in adults.

Clinical Chemical Laboratory Medicine, Walter de Gruyter

Print ISSN: 1434-6621
Volume: 44, 02/2006
Pages: 133 - 137

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