Taruna Madan, Shweta Saxena, Kolluri J. R. Murthy, Kambadur Muralidhar, Puranam Usha Sarma
Association of Polymorphisms in the Collagen
Region of Human SP-A1 and SP-A2 Genes with
Pulmonary Tuberculosis in Indian Population
Surfactant protein A (SP-A) binds to and modulates phagocytosis of Mycobacterium tuberculosis by macrophages. We investigated the relationship between polymorphisms in the collagen regions of SP-A1 and SP-A2 genes and pulmonary tuberculosis. In the present study, seven single nucleotide polymorphisms (SNPs) (4 exonic and 3 intronic) have been identified in the collagen regions of SP-A1 and SP-A2 genes in Indian population. Two intronic polymorphisms, SP-A1C1416T ((p = 0.0000, odds ratio (OR) = 20.767, 95% CI: 8.315SP-A2 gene showed significant association with pulmonary tuberculosis (number of patients = 17, number of controls = 19, p = 0.0000, OR = 8.94, 95% CI: 3.31
Clinical Chemical Laboratory Medicine, Walter de Gruyter
Print ISSN: 1434-6621
Volume: 40, 10/2002
Pages: 1002 - 1008
Show full article (external site)
Show all available items of this journal
Search
