J. J. Piazze, M. M. Anceschi, G. Picone, A. Cerekja, R. La Torre, E. V. Cosmi
Association between maternal-fetal Doppler velocimetry and fetal lung maturity
Aims: To correlate maternal-fetal Doppler velocimetry
parameters to indices of fetal lung maturity (FLM).
Methods: Fifty-five consecutive third trimester pregnancies
in which a pulsed-wave Doppler study, including
uterine resistance index (Ut RI), umbilical artery pulsatility
index (UA PI), middle cerebral artery pulsatility
index (MCA PI) and the UA/MCA ratio was performed
within 24 hours before amniocentesis and within a week
from birth. FLM was determined by amniotic fluid
lamellar bodies count (LBs).
Results: A positive correlation between MCA PI and
LBs (p < 0.007, r = 0.44) was found. MCA PI showed a
trend to lower values in fetuses that developed RDS at
birth (1.3±0.5 vs. 1.7±0.4, NS). LBs significantly decreased
as Ut RI increased (O.R.: 0.98, C.I. 0.97–0.99,
p < 0.05). A mean Ut RI > 0.64 was correlated to delayed
FLM (LBs < 20,000/?l; sensitivity: 90.9%, specificity:
90.3%; positive predictive value: 76.9%, negative predictive
value: 96.6%).
Comment: In third trimester pregnancies abnormal
uterine artery waveforms may be associated to a delayed
FLM, as expressed by decreased amniotic fluid LBs.
Journal of Perinatal Medicine, Walter de Gruyter
Print ISSN: 1619-3997
Volume: 31, 11/2003
Pages: 484 - 488
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