Bangwei Cao, Hongli Yang, Howard Ding, Suxia Qi, Lei Gao, Hong Cui, Yue Dai, Changqing Xu
Association analysis of hepatitis virus B infection with haplotypes of the TBX21 gene promoter region in the Chinese population
Background: The T-box21 (TBX21) gene encodes the transcription factor T-bet (T-box expressed in T-cells), which influences naive T-lymphocyte development and has been implicated in the pathogenesis of many diseases.
Methods: We selected 208 hepatitis B patients and 213 healthy volunteers to examine whether polymorphisms or haplotypes of the TBX21 gene promoter were associated with hepatitis B virus (HBV) infection in the Chinese population. Two polymorphisms at ?1499 and ?1514 located in the TBX21 promoter region were identified by the PCR-restriction fragment length polymorphism (PCR-RFLP) method.
Results: Single nucleotide polymorphism (SNP) at ?1499 was significantly different between HBV patients and healthy controls [p=0.003; odds ratio (OR) 3.65, 95% confidence interval (CI) 1.58–8.45]. Similarly, our results showed a significantly higher level of haplotype D (--/AC) in HBV patients compared to control subjects (p=0.005; OR 4.82, 95% CI 1.59–14.61).
Conclusions: Based on our findings, it seems that genetic variations of allele ?1499 and haplotype D (--/AC) within the TBX21 promoter region contribute to susceptibility to HBV infection in the Chinese population.
Clin Chem Lab Med 2007;45:333–8.
Clinical Chemical Laboratory Medicine, Walter de Gruyter
Print ISSN: 1434-6621
Volume: 45, 03/2007
Pages: 333 - 338
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