Loredan Stefan Niculescu, Jamila Fruchart-Najib, Jean-Charles Fruchart, Anca Sima
Apolipoprotein A-V gene polymorphisms in subjects with metabolic syndrome
Background: Genetic variation at the apolipoprotein A-V locus, recently discovered proximal to the APOA1/C3/A4 gene cluster, is associated with elevated triglyceride concentrations, a risk factor for atherosclerosis.
Methods: The goal of our study was to determine the association of two apolipoprotein A-V (APOA5) gene polymorphisms in a group of urban Romanian subjects with the prevalence of the metabolic syndrome. For this purpose, we assayed ?1.131T>C and c.56C>G polymorphisms for 279 subjects divided into three groups: a control group, a metabolic syndrome group and a cardiovascular disease group. Then we correlated the minor allele frequencies with body mass index and biochemical parameters.
Results: We obtained higher frequency for ?1.131C compared to c.56G alleles, both mainly distributed in overweight subjects. Body mass index and triglyceride levels were higher in ?1.131C allele carriers in metabolic syndrome patients, but were not significantly different in c.56G carriers compared to those with the native gene. Metabolic syndrome ?1.131C homozygotes presented lower high-density lipoprotein cholesterol and higher glucose levels compared to subjects with the native gene. Total cholesterol, low-density lipoprotein cholesterol and insulin were not different between ?1.131C or c.56G allele carriers and those with the native gene.
Conclusions: Our results demonstrate an independent risk for ?1.131T>C APOA5 gene polymorphisms in the development of metabolic syndrome.
Clin Chem Lab Med 2007;45
Clinical Chemical Laboratory Medicine, Walter de Gruyter
Print ISSN: 1434-6621
Volume: 04/2007
Pages: - - -
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