J. B. Moon, J. C. Kim, B. H. Yoon, R. Romero, G. Kim, S.-Y. Oh, M. Kim, S.-S. Shim
Amniotic fluid matrix metalloproteinase-8 and the development of cerebral palsy
Aims: To examine if increased concentrations of matrix
metalloproteinase-8 (MMP-8) in amniotic fluid are associated
with the development of cerebral palsy at the age
of three years.
Methods: The relationship between amniotic fluid concentrations
of MMP-8 and the development of cerebral
palsy was examined in 116 preterm singleton newborns
(gestational age at birth < 35 weeks) born to mothers
who underwent amniocentesis and were followed for at
least 3 years. Amniotic fluid was cultured for aerobic and
anaerobic bacteria and mycoplasmas. MMP-8 concentrations
were measured by specific immunoassays. Cerebral
palsy was diagnosed by neuro developmental assessment
at the age of three years.
Results: Median amniotic fluid concentration of MMP-8
was significantly higher in mothers whose newborns developed
cerebral palsy than in mothers whose newborns
did not develop cerebral palsy (median 153.9 [range
< 0.3–1535.9] ng/ml vs median 6.4 [range < 0.3–3836.8]
ng/ml; p < 0.01). Neonates who developed cerebral palsy
were delivered at earlier gestational age than those without
cerebral palsy. After adjustment for the gestational
age at birth and the results of amniotic fluid culture, elevated
concentrations of amniotic fluid MMP-8 significantly
increased the odds of development of cerebral
palsy (odds ratio, 6.0; 95% confidence interval, 1.1–33.0;
p < 0.05).
Conclusion: Increased concentrations of amniotic fluid
MMP-8 are associated with the subsequent development
of cerebral palsy at the age of 3 years.
Journal of Perinatal Medicine, Walter de Gruyter
Print ISSN: 1619-3997
Volume: 30, 07/2002
Pages: 301 - 306
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