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Petra Censarek, Anett Bobbe, Maria Grandoch, Karsten Schrr, Artur-Aron Weber

Alternatively spliced human tissue factor (asHTF) is not pro-coagulant

Keywords: Coagulation factors, tissue factor / factor VII, thrombosis

It has been proposed that alternatively-spliced human tissue factor (asHTF) is pro-coagulant. We have evaluated the function of asHTF in a mammalian expression system. Full-length human tissue factor (HTF) and asHTF were cloned from smooth muscle cells and over-expressed in HEK293 cells. As expected, a marked pro-coagulant activity (FX activation, thrombin generation) was observed on the surface, in lysates, and on microparticles from HTF transfected cells. In contrast, no pro-coagulant activity of asHTF was observed.

Thrombosis and Haemostasis, Schattauer

Print ISSN: 0340-6245
Volume: 97, 01/2007
Pages: 11 - 14

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