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Hidetomo Maruyoshi, Sunao Kojima, Tohru Funahashi, Shinzo Miyamoto, Jun Hokamaki, Hirofumi Soejima, Tomohiro Sakamoto, Hiroaki Kawano, Michihiro Yoshimura, Akira Kitagawa, Yuji Matsuzawa, Hisao Ogawa
Adiponectin is inversely related to plasminogen activator inhibitor type 1 in patients with stable exertional angina
Adipose tissue is a secretory organ producing a variety of bioactive substances, such as adiponectin. Adiponectin has antiatherogenic properties while plasminogen activator inhibitor type 1 (PAI-1) is closely involved in the development of atherosclerosis.The relationship between adiponectin and PAI-1 in patients with coronary artery disease (CAD) has not been clarified. This study examined plasma levels of adiponectin and PAI-1 in 64 patients with stable exertional angina (SEA) and 65 patients with the chest pain syndrome (CPS). Plasma log-adiponectin levels were significantly lower in patients with SEA (0.620.08 g/dL) compared to those with CPS (0.860.05 g/dL) (p<0.0001). The plasma levels of log-PAI-1 were significantly higher in patients with SEA (1.230.18 ng/mL) compared to those with CPS (1.150.22 ng/mL) (p<0.05). Plasma log-adiponectin levels correlated negatively with diabetes mellitus (DM), body mass index (BMI), log-PAI-1 (r=0.284, p<0.001), triglyceride (TG), and remnant-like particles cholesterol (RLP-C), and positively with high-density lipoprotein cholesterol (HDL-C) levels. Plasma levels of log-PAI-1 correlated positively with DM, BMI,TG and RLP-C levels, and negatively with HDL-C levels. Multiple logistic regression analysis identified sex, angina pectoris, and PAI-1 as independent determinants of hyperadiponectinemia (p<0.05). Adiponectin is inversely related to PAI-1. DM, BMI,TG, HDL-C, and RLP-C are common mediators between adiponectin and PAI-1, and treatment for common mediators may prevent the development of CAD by reducing PAI-1 and increasing adiponectin levels.
Thrombosis and Haemostasis, Schattauer
Print ISSN: 0340-6245
Volume: 91, 05/2004
Pages: 1026 - 1030