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Hans J. Naurath, Reiner Riezler, Sigurd Pütter, Johan B. Ubbink

Does a Single Vitamin B-Supplementation Induce Functional Vitamin B-Deficiency?

In a pilot study we measured the effect of three different combinations of the vitamins B₆, folate and B₁₂ on the serum concentrations of homocysteine, cystathionine and methylmalonic acid in five healthy young men without hyperhomocysteinemia. The results indicate that there are still undescribed interactions between vitamin B₆ and folate, suggesting that these two vitamins should be given together to avoid depletion of the one not given. With regard to the well known metabolic pathways of methionine and cysteine, this confirms the hypothesis that a combined supplementation with the vitamins B₆ and folate (and B₁₂) is superior to folate alone in order to lower homocysteine.

Clinical Chemical Laboratory Medicine, Walter de Gruyter

Print ISSN: 1434-6621
Volume: 39, 08/2001
Pages: 768 - 771

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