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Subash C. B. Gopinath, Yasuo Shikamoto, Hiroshi Mizuno, Penmetcha K. R. Kumar

A potent anti-coagulant RNA aptamer inhibits blood coagulation by specifically blocking the extrinsic clotting pathway

Keywords: Aptamer, blood coagulation, extrinsic and intrinsic pathway, inhibition, RNA

A potent antidote-controlled aptamer, as an anticoagulant, has reportedly overcome the complications of acute bleeding by the administration of available anticoagulants. In the present study, we provide evidence that the aptamer binds specifically to factors IX and IXa and inhibits their functions. Furthermore, we demonstrated that the aptamer inhibits blood coagulation by interfering with the extrinsic pathway, blocking the complex of factor VIIa and tissue factor interactions with factor IX. The results from the previous and present studies suggest that the aptamer probably binds in the vicinity of the EGF1 and EGF2 domains of factor IX.

Thrombosis and Haemostasis, Schattauer

Print ISSN: 0340-6245
Volume: 95, 05/2006
Pages: 767 - 771

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