You are here: Home :: Area NEM :: Medical science :: Human medicine

Phyllis E. McGowan, William C. Lawrie, John Reglinski, Corinne M. Spickett, Rhoda Wilson, James J. Walker, Steven Wisdom, Marjorie A. Maclean

¹H NMR as a non-invasive probe of amniotic fluid in insulin dependant diabetes mellitus

Ten amniotic fluid samples obtained from third trimester pregnant women suffering from insulin dependant diabetes mellitus were analysed by ¹H-NMR and compared to ten samples from a group of normal volunteers. A subset of the metabolites identified; valine, lactate, alanine, acetate, citrate and glucose were quantitated using standard addition methods. Apart from valine and citrate, a general diminution in the concentration of each of these species was found, especially glucose, in the diabetic group. The abnormally low glucose levels in the diabetic group are suggestive of infection in the patient group. However, the depressed lactate levels in the diabetic group suggest that in these cases the fetus was not subjected to stress.

Journal of Perinatal Medicine, Walter de Gruyter

Print ISSN: 1619-3997
Volume: 27, 11/1999
Pages: 404 - 408

Show full article (external site)

Show all available items of this journal

 

Area NEM