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Carla R.O. Carvalho, Lucimara Maeda, Sigisfredo L. Brenelli, Mario J.A. Saad

Tissue-Specific Regulation of IRS-2/PI 3-Kinase Association in Aged Rats

We have examined the insulin-stimulated IRS-2 association with PI 3-kinase and the phosphorylation of AKT/PKB, which is functionally located downstream of the PI 3-kinase, in aged (obese) rats. The IRS-2 protein levels were similar in 2 and 20 month-old rats in both tissues, liver and muscle. There were reductions in insulin-induced IRS-2 tyrosine phosphorylation in liver and muscle, accompanied by a decrease in IRS-2/PI 3-kinase association and in AKT/PKB phosphorylation only in muscle tissue of aged rats. This regulation may be important in the altered glucose metabolism observed in aged (obese) rats.

Biological Chemistry, Walter de Gruyter

Print ISSN: 1431-6730
Volume: 381, 01/2000
Pages: 75 - 78

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