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Ernst J.M. Helmreich

Structural flexibility of small GTPases. Can it explain their functional versatility?

Keywords: cellular constraints, coupling versatility, flexible proteins, GTPase structure, small GTPases

Multiple interactions with many different partners are responsible for the amazing functional versatility of proteins, especially those participating in cellular regulation. The structural properties that could facilitate multiple interactions are examined for small GTPases. The role of cellular constraints, compartmentation and scaffolds on protein-protein interactions is considered.

Biological Chemistry, Walter de Gruyter

Print ISSN: 1431-6730
Volume: 385, 12/2004
Pages: 1121 - 1136

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