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T. Hofer, R. Pohjanvirta, P. Spielmann, M. Viluksela, D. P. Buchmann, R. H. Wenger, M. Gassmann

Simultaneous exposure of rats to dioxin and carbon monoxide reduces the xenobiotic but not the hypoxic response

Aryl hydrocarbon receptor (AhR) and hypoxiainducible factor-1? (HIF-1?) are conditionally regulated transcription factor subunits that form heterodimeric complexes with their common partner, AhR nuclear translocator (ARNT/HIF-1?). Whereas the environmentally toxic compound 2,3,7,8-tetra-chlorodibenzo-p-dioxin (TCDD) initiates the trans-activation activity of AhR:ARNT/HIF-1?, hypoxic exposure stabilizes HIF-1? and functionally activates the HIF-1?:ARNT/HIF-1? complex. To analyze a possible crosstalk between these two pathways in vivo, rats were given dioxin orally and/or were exposed to carbon monoxide (CO), causing functional anemia. We found that exposure to CO inhibited the xenobiotic response while dioxin application had no significant negative impact on hypoxia-mediated gene transcription.

Biological Chemistry, Walter de Gruyter

Print ISSN: 1431-6730
Volume: 385, 04/2004
Pages: 291 - 294

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