You are here: Home :: Area NEM :: Life sciences :: Biochemistry

Haruhiro Higashida, Shigeru Yokoyama, Naoto Hoshi, Minako Hashii, Alla Egorova, Zhen-Guo Zhong, Mami Noda, Mohammad Shahidullah, Megumi Taketo, Rimma Knijnik, Yasuhiro Kimura, Hiroto Takahashi, Xiao-Liang Chen, Yeonsook Shin, Jia-Sheng Zhang

Signal Transduction from Bradykinin, Angiotensin, Adrenergic and Muscarinic Receptors to Effector Enzymes, Including ADP-Ribosyl Cyclase

Muscarinic acetylcholine receptors in NG108-15 neuroblastoma x glioma cells, and ?-adrenergic or angiotensin II receptors in cortical astrocytes and/or ventricular myocytes, utilize the direct signaling pathway to ADP-ribosyl cyclase within cell membranes to produce cyclic ADP-ribose (cADPR) from ?-NAD⁺. This signal cascade is analogous to the previously established transduction pathways from bradykinin receptors to phospholipase C? and ?-adrenoceptors to adenylyl cyclase via G proteins. Upon receptor stimulation, the newlyformed cADPR may coordinately function to upregulate the release of Ca²⁺ from the type II ryanodine receptors as well as to facilitate Ca²⁺ influx through voltage-dependent Ca²⁺ channels. cADPR interacts with FK506, an immunosuppressant, at FKBP12.6, FK506-bindingprotein, and calcineurin, or ryanodine receptors. cADPR also functions through activating calcineurin released from Akinase anchoring protein (AKAP79). Thus, some G_q/11coupled receptors can control cADPR-dependent modulation in Ca²⁺ signaling.

Biological Chemistry, Walter de Gruyter

Print ISSN: 1431-6730
Volume: 382, 02/2001
Pages: 23 - 30

Show full article (external site)

Show all available items of this journal

 

Area NEM