You are here: Home :: Area NEM :: Life sciences :: Biochemistry

M. Metzlaff

RNA-Mediated RNA Degradation in Transgene- and Virus-Induced Gene Silencing

In the RNA world hypothesis it is postulated that RNA was the first genetic molecule. Recent discoveries in gene silencing research on plants, fungi and animals show that RNA indeed plays a key role not only in controlling invading nucleic acids, like viruses and transposable elements, but also in regulating the expression of transgenes and endogenous genes. Doublestranded RNAs were identified to be the triggering structures for the induction of a specific and highly efficient RNA silencing system, in which enzyme complexes, like Dicer and RISC, facilitate as molecular machines the processing of dsRNA into characteristic small RNA species. RNA silencing can be transmitted rapidly from silenced to nonsilenced cells by short and long distance signaling. There is evidence that at least one component of the signal is a specific, degradationresistant RNA.

Biological Chemistry, Walter de Gruyter

Print ISSN: 1431-6730
Volume: 383, 10/2002
Pages: 1483 - 1489

Show full article (external site)

Show all available items of this journal

 

Area NEM