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Franois Lpine, Valrie Dekimpe, Biliana Lesic, Sylvain Milot, Alain Lesimple, Orval A. Mamer, Laurence G. Rahme, Eric Dziel

PqsA is required for the biosynthesis of 2,4-dihydroxyquinoline (DHQ), a new metabolite produced by Pseudomonas aeruginosa and Burkholderia thailandensis

Keywords: 2,4-dihydroxyquinoline, 4-hydroxy-2-alkylquinolines, Mass spectrometry, natural product, Pseudomonas aeruginosa, PqsA

A new metabolite, 2,4-dihydroxyquinoline (DHQ), was identified in cultures of the bacteria Pseudomonas aeruginosa and Burkholderia thailandensis. We found that the biosynthesis of DHQ correlates with the presence of a functional PqsA, which is product of the pqsABCDE operon responsible for the synthesis of 4-hydroxy-2-alkylquinolines (HAQs) in P. aeruginosa. However, DHQ is not a degradation product or a precursor of HAQs. This finding sheds light on the poorly understood biosynthesis pathway of HAQs, which include important communication signals regulating the expression of virulence factors.

Biological Chemistry, Walter de Gruyter

Print ISSN: 1431-6730
Volume: 2007
Pages: -

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