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Karl-Heinz Wiesmüller, Burkhard Fleckenstein, Günther Jung
Peptide Vaccines and Peptide Libraries
Synthetic immunogens, containing builtin adjuvanticity, B cell, T helper cell and CTL epitopes or mimotopes, are ideal and invaluable tools to study the immune response with respect to antigen processing and presentation. This serves as a basis for the development of complete and minimal vaccines which not need large carrier proteins, further adjuvants, liposome formulations or other delivery systems. Combinatorial peptide libraries, either completely random or characterized by one or several defined positions, are useful tools for the identification of the critical features of B cell epitopes and MHC class I and class II binding natural and synthetic epitopes. The complete activity pattern of O/X library with hundreds of peptide collections, each made up from billions of different peptides, represents the ranking of amino acid residues mediating contact to the target proteins of the immune system. Combinatorial libraries support the design of peptides applicable in vaccination against infectious agents as well as therapeutic tumour vaccines. Using the principle of lipopeptide vaccines, strong humoral and cellular immune responses could elicited. The lipopeptide vaccines are heatstable, nontoxic, fully biodegradable and can be prepared on the basis of minimized epitopes by modern methods of multiple peptide synthesis. The lipopeptides activate the antigenpresenting macrophages and cells and have been recently shown to stimulate innate immunity by specific interaction with receptors of the Toll family.
Biological Chemistry, Walter de Gruyter
Print ISSN: 1431-6730
Volume: 382, 04/2001
Pages: 571 - 579