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M. Maiorino, F. Ursini

Oxidative Stress, Spermatogenesis and Fertility

Reactive oxygen species production and glutathione depletion in mammalian male germ cells are physiological events that are requisite to the functional maturation and capacitation of spermatozoa. In relation to this oxidative stress, an oxidation of the bulk of protein sulfydryl groups takes place during the final phases of male germ cell maturation. The selenoenzyme phospholipid hydroperoxide glutathione peroxidase catalyzes this reaction, and accounts for both the assembly of the midpiece of spermatozoa and chromatin condensation. This process highlights the role of H2O2 and selenium in spermatogenesis and provides a mechanism for coupling a physiologically controlled oxidative stress to a specialized phenotypic function.

Biological Chemistry, Walter de Gruyter

Print ISSN: 1431-6730
Volume: 383, 04/2002
Pages: 591 - 597

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