You are here: Home :: Area NEM :: Life sciences :: Biochemistry

I. von Lüttichau, R. Djafarzadeh, A. Henger, C. D. Cohen, A. Mojaat, M. Jochum, C. Ries, P. J. Nelson, M. Kretzler

Identification of a Signal Transduction Pathway That Regulates MMP-9 mRNA Expression in Glomerular Injury

Podocytes contribute to the filtration barrier within the kidney. The integrinlinked kinase (ILK) plays an important role in podocyte adhesion to the glomerular basement membrane, signal transduction and phenotype regulation. We demonstrate that ILK activity is also associated with upregulation of matrix metalloproteinase 9 (MMP-9) mRNA levels during podocyte stress. A synthetic ILK inhibitor blocked MMP-9 mRNA upregulation but showed no effect on TIMP-1 or MMP-2 mRNA expression. Interestingly, a corresponding increase in MMP-9 secretion was not observed, suggesting that MMP-9 mRNA production in podocytes is regulated via ILK, whereas additional signaling pathways may mediate the posttranscriptional regulation of MMP-9.

Biological Chemistry, Walter de Gruyter

Print ISSN: 1431-6730
Volume: 383, 08/2002
Pages: 1271 - 1275

Show full article (external site)

Show all available items of this journal

 

Area NEM