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Andrea Huwiler, Josef Pfeilschifter
Hypoxia and lipid signaling
Keywords: eicosanoids, Gene expression, hypoxia, hypoxia-inducible factor, signal transduction, sphingolipids
Sufficient oxygen supply is crucial for the development and physiology of mammalian cells and tissues. When simple diffusion of oxygen becomes inadequate to provide the necessary flow of substrate, evolution has provided cells with tools to detect and respond to hypoxia by upregulating the expression of specific genes, which allows an adaptation to hypoxia-induced stress conditions. The modulation of cell signaling by hypoxia is an emerging area of research that provides insight into the orchestration of cell adaptation to a changing environment. Cell signaling and adaptation processes are often accompanied by rapid and/or chronic remodeling of membrane lipids by activated lipases. This review highlights the bi-directional relation between hypoxia and lipid signaling mechanisms.
Biological Chemistry, Walter de Gruyter
Print ISSN: 1431-6730
Volume: 387, 10/2006
Pages: 1321 - 1328