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R. Stohwasser, H.-G. Holzhütter, U. Lehmann, P. Henklein, P.-M. Kloetzel

Hepatitis B Virus HBx Peptide 116–138 and Proteasome Activator PA28 Compete for Binding to the Proteasome ?4/MC6 Subunit

PA28 is a modulator of the 20S proteasome. The PA28 binding sites on the 20S proteasome are still not well defined. Using yeast two-hybrid interaction assays and proteasome inactivation kinetics we provide evidence that the proteasome ?4 subunit is one of the PA28 binding sites. This finding is supported by the observation that a hepatitis Bvirus X protein-derived polypeptide habouring the ?4 proteasome subunit binding motif impairs the activation of 20S proteasomes by PA28.

Biological Chemistry, Walter de Gruyter

Print ISSN: 1431-6730
Volume: 384, 01/2003
Pages: 39 - 49

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