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Charles N. Pagel, Sutharshani Sivagurunathan, Lay Hoon Loh, Elizabeth M. Tudor, Robert N. Pike, Eleanor J. Mackie

Functional responses of bone cells to thrombin

Keywords: bone healing, intracellular calcium, osteoblast, osteoclast, phosphoinositol metabolism, prostaglandins, protease-activated receptor, thrombin

Cells responsible for the formation and maintenance of bone express thrombin-responsive members of the protease-activated receptor family of G protein-coupled receptors. Thrombin has been shown to elicit a number of functional responses in these cells, including proliferation and cytokine production in osteoblasts. Many, but not all, of the effects of thrombin on bone cells are initiated by activation of protease-activated receptor-1. A combination of in vitro observations and results of in vivo studies in protease-activated receptor-1-null mice suggest that thrombin plays multiple roles in the early stages of bone healing.

Biological Chemistry, Walter de Gruyter

Print ISSN: 1431-6730
Volume: 387, 08/2006
Pages: 1037 - 1041

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