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Kishorchandra Gohil

Functional genomics identifies novel and diverse molecular targets of nutrients in vivo

Keywords: antioxidants, ataxia, neurodegeneration, oligodendrocyte, polyphenols, retinoic acid related orphan receptor, tocopherol transfer protein, transcription regulatory networks

Genomic responses to nutrients are important determinants of physiological and pathological functions of living systems. Many of these responses are mediated by changes in mRNA concentrations that are primarily regulated by gene transcription. Transcriptional networks that regulate the expression and activities of transcription factors and structural genes in response to nutrients need to be defined. The tools of functional genomics and bioinformatics offer powerful means to address these needs. The application of global mRNA profiling tools to define genome-wide responses to nutrients and micronutrients with a primary focus on in vivo genomic responses of vital organs of laboratory mice is reviewed here. The studies show that major and minor nutrients affect the expression of mRNAs that are related to aging and inflammation, and chemically diverse micronutrients such as polyphenols and tocopherols may exert their effects through modulating the expression of functionally related genes.

Biological Chemistry, Walter de Gruyter

Print ISSN: 1431-6730
Volume: 385, 08/2004
Pages: 691 - 696

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