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Dusanka Milenkovic, Judith Mller, Diana Stojanovski, Nikolaus Pfanner, Agnieszka Chacinska

Diverse mechanisms and machineries for import of mitochondrial proteins

Keywords: complex assembly, disulfide bonds, mitochondria, protein import, protein sorting, translocase

Mitochondria are ubiquitous organelles that play an essential role in energy conversion and biosynthetic pathways of eukaryotic cells. Most mitochondrial proteins must be imported from the cytosol and sorted into one of the four mitochondrial subcompartments, outer membrane, intermembrane space, inner membrane and matrix. Studies of recent years revealed a remarkable diversity of mechanisms and machineries that are required for the import of proteins into mitochondria. At least four different pathways for the sorting and assembly of nuclear-encoded mitochondrial proteins have been identified.

Biological Chemistry, Walter de Gruyter

Print ISSN: 1431-6730
Volume: 2007
Pages: -

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