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S. T. Safrany, J. J. Caffrey, X. Yang, S. B. Shears

Diphosphoinositol Polyphosphates: The Final Frontier for Inositide Research?

The diphosphoinositol polyphosphates comprise a group of highly phosphorylated compounds which have a rapid rate of metabolic turnover through tightly-regulated kinase/phosphohydrolase substrate cycles. The phosphohydrolases occur as multiple isoforms, the expression of which is apparently carefully controlled. Cellular levels of the diphosphoinositol polyphosphates are regulated by cAMP and cGMP in a protein kinase-independent manner. These inositides can also sense a specific mode of intracellular Ca²⁺ pool depletion. In this review, we will argue that these are characteristics of highly significant cellular molecules.

Biological Chemistry, Walter de Gruyter

Print ISSN: 1431-6730
Volume: 380, 07/1999
Pages: 945 - 951

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