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A. ?edo, P. Bu?ek, E. Scholzová, R. Malík, K. Vla?icová, S. Janá?ková, V. Mare?

'Dipeptidyl peptidase-IV activity and/or structure homologs' (DASH) in growth-modulated glioma cell lines

Dipeptidyl peptidase-IV has been demonstrated to play a role in cancer biology by many authors. Since then, additional proteins possessing similar enzymatic activity have been described and their role in cancerogenesis has been hypothesized. To assess the complexity of these Dipeptidyl peptidase-IV activity and/or structure homologs (DASH) in glioma cells, we have studied their presence in cell lines of different degree of transformation. Our results provide evidence of cell linespecific expression and distribution of dipeptidyl peptidaseIV enzyme activity-bearing molecules and their dynamics associated with cell growth conditions. The biologic outcome of DASH pattern of composition probably depends on the regulatory peptides/DASH substrates in the cellular environment.

Biological Chemistry, Walter de Gruyter

Print ISSN: 1431-6730
Volume: 385, 06/2004
Pages: 557 - 559

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