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F. Bühling, U. Peitz, S. Krüger, D. Küster, M. Vieth, I. Gebert, A. Roessner, E. Weber, P. Malfertheiner, T. Wex

Cathepsins K, L, B, X and W are differentially expressed in normal and chronically inflamed gastric mucosa

The expression of cathepsins K, L, B, X and W was studied by quantitative RT-PCR in normal and inflamed gastric mucosa (antrum, corpus, cardia). Cathepsins B, L, K and X were expressed ubiquitously. In contrast, cathepsin W was expressed at very low levels. Infection by Helicobacter pylori caused a significant induction of cathepsin X (p<0.008), whereas the other cathepsins were not or only locally affected by H. pylori infection or reflux disease. Immunohistochemistry revealed specific expression of cathepsin X (macrophages), cathepsin K (parietal cells) and cathepsin W (lymphocytes), whereas cathepsins B and L were predominantly expressed in epithelial cells.

Biological Chemistry, Walter de Gruyter

Print ISSN: 1431-6730
Volume: 385, 05/2004
Pages: 439 - 445

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