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Mami Noda, Helmut Kettenmann, Keiji Wada

Anti-inflammatory effects of kinins via microglia in the central nervous system

Keywords: bradykinin, IL-1?, lipopolysaccharide, nitric oxide, prostaglandin E2, TNF-?

Kinins are important biologically active peptides that are up-regulated after lesions in both the peripheral and central (CNS) nervous systems. Microglia are immune cells in the CNS and play an important role in the defense of the neuronal parenchyma. In cultured murine microglia, bradykinin (BK) induces mobilization of intracellular Ca²⁺, microglial migration, and increases the release of nitric oxide and prostaglandin E₂. On the other hand, BK attenuates lipopolysaccharide-activated TNF-? and IL-1? release. These results suggest that BK functions as a signal in brain trauma and may have an anti-inflammatory role in the CNS.

Biological Chemistry, Walter de Gruyter

Print ISSN: 1431-6730
Volume: 387, 02/2006
Pages: 167 - 171

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