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A. Lamberti, A. Petrella, M. Pascale, M.F. Romano, R. Bisogni, N. Vita, S. Venuta, M.C. Turco

Activation of NF-?B/Rel transcription factors in human primary peripheral blood mononuclear cells by interleukin 7

Pathways that regulate the activation of NF-?B/Rel transcription factors are known to include signaling through a number of cytokine receptors. Interleukin 7 (IL-7), produced by bone marrow and other stromal cells, is a key factor for differentiation and survival in the lymphoid and other compartments. We found that human recombinant IL-7 induced NF-?B/Rel activation, analyzed by electrophoretic mobility shift assay (EMSA), in human peripheral blood T lymphocytes from healthy donors. Induced complexes included p65 and p50 NF-?B/Rel subunits. These results demonstrate for the first time that IL-7 can participate in signaling leading to NF-?B/Rel activation.

Biological Chemistry, Walter de Gruyter

Print ISSN: 1431-6730
Volume: 385, 05/2004
Pages: 415 - 417

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