You are here: Home :: Area NEM :: Computer science

Adelinde Uhrmacher, Céline Kuttler

Multi-Level Modeling in Systems Biology by Discrete Event Approaches

Keywords: modeling, Simulation, Simulation Languages, Multi-Level Modeling, Discrete-Event Modeling

The creation of models for heterogeneous and complex cellular networks is a central goal of Systems Biology. When modeling a biological network, one may wish to account for certain aspects in detail, while a bird´s eye perspective would seem more appropriate for other parts. Multi-level models combine such overview and detail representations. We illustrate multi-level modeling with gene regulation of the Tryptophan operon in E. coli. We review three discrete event modeling formalisms and discuss model design therein: DEVS, STATECHARTS, and stochastic π-CALCULUS. This introductory presentation already reveals some of their respective virtues and shortcomings.

it – Information Technology (vormals it+ti), Oldenbourg Wissenschaftsverlag

Print ISSN: 1611-2776
Volume: 48, 03/2006
Pages: 148 - 153

Show full article (external site)

Show all available items of this journal

 

Area NEM