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Gerard C. Krijger, Marjan M. Fretz, Ula D. Woroniecka, Olav M. Steinebach, Wim Jiskoot, Gert Storm, Gerben A. Koning

Tumor cell and tumor vasculature targeted liposomes for neutron capture therapy

Treatment of cancer using boron neutron capture therapy requires the specific accumulation of a relatively high concentration of ¹⁰B into tumor cells or tumor vasculature. In this paper, targeted liposomes were evaluated as carriers of ¹⁰B for this purpose. Na₂ ¹⁰B₁₂H₁₂ was successfully encapsulated into liposomes and relatively high amounts of ¹⁰B could be targeted to ovarian carcinoma cells (OVCAR-3) and endothelial cells (HUVEC). This was achieved by coupling a monoclonal antibody or an RGD peptide to the liposomes. The results suggest that targeted liposomes could meet the requirements of successful neutron capture therapy in the near future.

Radiochimica Acta, Oldenbourg Wissenschaftsverlag

Print ISSN: 0033-8230
Volume: 93, 09/2005
Pages: 589 - 593

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