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Rupasri Mandal (Karan), J. Gangopadhyay, Sujit Chandra Lahiri

Studies on Hydrophobic Interaction from the Conductometric Studies of Medicinal Compounds (as Salts)

The Λ₀ values and association constants of some salts of medicinal interest in aqueous solution have been determined. The division of Λ₀ of salts into single ion values λ⁰₊ and λ⁰₋ have been made using λ⁰_Na+ and λ⁰_Cl− values from the literature. The Λ₀, λ⁰₊ and λ⁰₋ values have been found to be fairly high in aqueous solution and comparatively lesser than those in acetonitrile. Most of the drugs have been found to be dissociated as ions though association of some of the salts has been observed. The calculations of r_± of ions in water show considerable decrease in the radii values of ions in water from which inference regarding the extent of hydrophobic interactions can be made.

Zeitschrift für Physikalische Chemie, Oldenbourg Wissenschaftsverlag

Print ISSN: 0942-9352
Volume: 219, 06/2005
Pages: 795 - 805

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