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Wolfgang Wadsak, Leonhard-Key Mien, Dagmar E. Ettlinger, Rupert Lanzenberger, Daniela Haeusler, Robert Dudczak, Kurt Kletter, Markus Mitterhauser

Simple and fully automated preparation of [carbonyl-¹¹C]WAY-100635

Keywords: WAY-100635, Serotonin, 5-HT, Radiosynthesis, Carbon-11

So far, [carbonyl-¹¹C]WAY-100635 is the PET-tracer of choice for 5HT_1A-receptor-imaging. Since the preparation is still a challenge, we aimed at (1) the evaluation of various essential parameters for the successful preparation, (2) the simplification of the radiosynthesis and (3) the establishment of a safe and fully automated system. The preparation is based on a commercial synthesizer and all chemicals are used without further processing. We found a low failure rate (7.7%), high average yield (4.0±1.0 GBq) and a specific radioactivity of 292±168 GBq/μmol (both at the end of synthesis, EOS).

Radiochimica Acta, Oldenbourg Wissenschaftsverlag

Print ISSN: 0033-8230
Volume: 95, 07/2007
Pages: 417 - 422

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