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A. R. Jalilian, P. Rowshanfarzad, M. Sabet

Preparation of [⁶¹Cu]pyruvaldehyde-bis (N⁴-methylthiosemicarbazone) complex as a possible PET radiopharmaceutical

Keywords: Copper-61, PTSM, Radiopharmaceutical, Cyclotron, PET

Copper-61 (T_1/2=3.33 h) produced via the ^natZn(p,x) ⁶¹Cu nuclear reaction using natural zinc target, was separated from the irradiated target material by a two-step method developed in our laboratory and was used for the preparation of [⁶¹Cu]-pyruvaldehyde- bis (N⁴-methylthiosemicarbazone) ([⁶¹Cu]-PTSM) using an in house-made PTSM ligand. An electroplated natural zinc layer on a gold-coated copper backing (zinc and gold layer thicknesses were 80 and 50 μm respectively) was irradiated with 22 MeV; protons (22−12 MeV; on the target). ⁶¹Cu was separated by a two-step chromatography method using a cation and an anion exchange column which gave satisfactory results. After 180 μA irradiation of the target for 3.2 hours, about 6.006 Ci of ⁶¹Cu²⁺ was obtained with a radiochemical separation yield of more than 95% and a radionuclidic purity of more than 99% (⁶⁰Cu as impurity). Colorimetric methods showed that traces of chemical impurities in the product were below the accepted limits. The solution of [⁶¹Cu]-PTSM was prepared with a radiochemical yield of higher than 80%, radiochemical purity of better than 98% and specific activity of about 246 Ci/mmol.

Radiochimica Acta, Oldenbourg Wissenschaftsverlag

Print ISSN: 0033-8230
Volume: 94, 02/2006
Pages: 113 - 117

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