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A. Mushtaq, S. Pervez, I. Haider

Preparation of ¹⁸⁸Re-lanreotide peptide and its quality control

A simple method is described for the preparation of ¹⁸⁸Re-Lanreotide, a radiolabeled synthetic peptide derived from an analogue of somatostatin, using Lanreotide (50 μg) and stannous tartrate to which is added carrier-free ¹⁸⁸Re. The radiolabeling has been carried out with ~555 MBq (15 mCi) with a >95% labeling efficiency and no need for subsequent purification. ITLC and HPLC techniques were employed for monitoring the stability and labeling yield. Radiolabeling results in one major peak when analyzed by reverse-phase (RP) HPLC.

Radiochimica Acta, Oldenbourg Wissenschaftsverlag

Print ISSN: 0033-8230
Volume: 88, 08/2000
Pages: 495

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