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Tanveer Hussain Bukhari, A. Mushtaq, Islam Ullah Khan

Lead (Pb) column for concentration of ^99mTc-pertechnetate

Keywords: Post-elution concentration of 99mTc-pertechnetate, In house prepared lead (Pb) column, 99Mo-99mTc generator

Because of the high content of inactive molybdenum in neutron irradiated MoO₃, large columns containing alumina or gel are needed to produce chromatographic ⁹⁹Mo→^99mTc generator. This results in large elution volumes containing relatively high ⁹⁹Mo breakthrough and low concentrations of ^99mTcO₄^-. The decrease in specific volume of ^99mTc places a limitation on reconstitution of some kits for ^99mTc radiopharmaceuticals applied in diagnostic nuclear medicine. Hence concentration technique is mandatory for effective utilization of (n,γ) produced ⁹⁹Mo/^99mTc generators at the start of its life whereas in case of fission ⁹⁹Mo/^99mTc generator the technique may be quite useful at the end of first week of its life. We report post elution concentration of ^99mTc using in house prepared Pb column. The high bolus volumes (10-60 ml saline) can conveniently be concentrated in ∼1 ml of saline.

Radiochimica Acta, Oldenbourg Wissenschaftsverlag

Print ISSN: 0033-8230
Volume: 95, 11/2007
Pages: 663 - 667

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