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J. Chamoun, A. Hagège

Contribution of hyphenated CE-ICP/MS in metal/protein interactions studies

By introducing a preliminary in-capillary preconcentration step, CE-ICP/MS was applied to trace metal speciation in proteins. Emphasis was put on metal/protein interactions where CE-ICP/MS is demonstrated to provide informations concerning metal binding and metal exchanges occuring in proteins. Preliminary studies on the fate of several metals in the presence of a mixture of standard proteins were performed. Cadmium was shown to bind mainly to albumin and ceruloplasmin. Cobalt and nickel were detected only in carbonic anhydrase and ceruloplasmin in the mixture of proteins but also in albumin when injected alone.

Radiochimica Acta, Oldenbourg Wissenschaftsverlag

Print ISSN: 0033-8230
Volume: 93, 11/2005
Pages: 659 - 664

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