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Dirk Roeda, Christian Crouzel, Frédéric Dollé

A rapid, almost quantitative conversion of [¹¹C]carbon dioxide into [¹¹C]carbon monoxide via [¹¹C]formate and [¹¹C]formyl chloride

[¹¹C]Formic acid can be produced from no-carrier-added [¹¹C]carbon dioxide reliably and instantaneously in almost quantitative radiochemical yield using lithium triethylborohydride in THF. It can react, either on a solid support or as its non-hydrolysed LiEt₃B-adduct, with a complex formed from hexachloroacetone and triphenylphosphine in THF at room temperature to give, again almost quantitatively, [¹¹C]formyl chloride. The latter decomposes instantaneously to give [¹¹C]carbon monoxide, providing an interesting alternative for current methods of [¹¹C]carbon monoxide production in radiopharmaceutical chemistry. [¹¹C]Formyl chloride has also potential in low-temperature N-formylation.

Radiochimica Acta, Oldenbourg Wissenschaftsverlag

Print ISSN: 0033-8230
Volume: 92, 04/2004
Pages: 329 - 332

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