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E.M. Holt, G.A. Caignan

New 1,4-dihydropyridine derivatives with C4 heterocyclic substituents

4-(2-Pyrrolyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-bis(methoxycarbonyl), 4-(3-furyl)-2,6-dimethyl-1,4-di-hydropyridine-3,5-bis(methoxycarbonyl) and 4-(3-bromo-2-furyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-bis(methoxy-carbonyl) are potential antiarrhythmic pharmaceuticals with Ca²⁺ antagonistic activity in L type voltage gated channels. Conformation of the 3 and 5 substituted carbonyl groups appears influenced by hydrogen bonding with ap orientation observed for carbonyl groups serving as H-bonding acceptor groups in the solid. This behavior appears to mimic in vivo conformational preferences.

Zeitschrift für Kristallographie, Oldenbourg Wissenschaftsverlag

Print ISSN: 0044-2968
Volume: 215, 02/2000
Pages: 122

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