Shang-Tzen Chang, Sheng-Yang Wang, Chi-Lin Wu, Pin-Fun Chen, Yueh-Hsiung Kuo
Comparison of the Antifungal Activity of Cadinane Skeletal Sesquiterpenoids from Taiwania (Taiwania cryptomerioides Hayata) Heartwood
Summary
The antifungal activity of cadinane skeletal sesquiterpenoids from Taiwania (Taiwania cryptomerioides
Hayata) heartwood is demonstrated. Using spectral analyses, the absolute structures of three main cadinanes,
T-cadinol, T-muurolol, and ?-cadinol, all isolated from Taiwania with HPLC, were identified.
The amount of these cadinanes was also quantified using GC. The results showed that the total amount
of cadinanes extracted from heartwood with n-C6H14 was 6.49 mg per kg of wood. This was much more
than the essential oils collected by water distillation from leaves (0.04 mg/kg), sapwood (0.36 mg/kg),
or heartwood (1.77 mg/kg). Moreover, results obtained from the antifungal assays demonstrated that ?cadinol
exhibited the highest antifungal index for both Coriolus versicolor and Laetiporus sulphureus,
followed by T-cadinol and T-muurolol. As a matter of fact, ?-cadinol completely inhibited the growth of
C. versicolor and L. sulphureus at the level as low as 100 ppm. Further comparison of the molecular configuration
of these cadinanes reveals that cadinane skeletal sesquiterpenoids with an equatorial hydroxyl
group at C-9 and a trans configuration at the ring junction, such as the case for ?-cadinol, exhibited
the strongest antifungal activity.
Holzforschung, Walter de Gruyter
Print ISSN: 0018-3830
Volume: 54, 04/2000
Pages: 241 - 245
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